Christopher Winrow : rechercher sur Z-Library

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1

Orexin Receptors: Pharmacology and Therapeutic Opportunities

Scammell, Thomas E., Winrow, Christopher J.

Journal:

Annual Review of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2011

2

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

Gotter, Anthony L., Winrow, Christopher J., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne

Journal:

Journal of Neurogenetics

Année:

2011

Langue:

english

Fichier:

PDF, 416 KB

english, 2011

3

The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia

Coleman, Paul J., Gotter, Anthony L., Herring, W. Joseph, Winrow, Christopher J., Renger, John J.

Journal:

Annual Review of Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 2.40 MB

english, 2017

4

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

Christopher D. Cox, Georgia B. McGaughey, Michael J. Bogusky, David B. Whitman, Richard G. Ball, Christopher J. Winrow, John J. Renger, Paul J. Coleman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 534 KB

english, 2009

5

Distribution of histone deacetylases 1–11 in the rat brain

Ron S. Broide, Jeff M. Redwine, Najla Aftahi, Warren Young, Floyd E. Bloom, Christopher. J. Winrow

Journal:

Journal of Molecular Neuroscience

Année:

2007

Langue:

english

Fichier:

PDF, 8.19 MB

english, 2007

6

The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts

Vivienne R. Winrow, Jon Mesher, Sajeda Meghji, Christopher J. Morris, Maria Maguire, Simon Fox, Anthony R. M. Coates, Peter Tormay, David R Blake, Brian Henderson

Journal:

Cellular Microbiology

Année:

2008

Langue:

english

Fichier:

PDF, 405 KB

english, 2008

7

Interplay of the Peroxisome Proliferator-activated Receptor and the Thyroid Hormone Receptor-signaling Pathways in Regulating Peroxisome Proliferator–responsive Genes

CHRISTOPHER J. WINROW, ALTAF KASSAM, KENJI S. MIYATA, SANDRA L. MARCUS, JOHN HUNTER, JOHN P. CAPONE, RICHARD A. RACHUBINSKI

Journal:

Annals of the New York Academy of Sciences

Année:

1996

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1996

8

Capacity of UV-lrradiated Human Fibroblasts to Support Adenovirus DNA Synthesis Correlates with Transcription-Coupled Repair and is Reduced in SV40-Transformed Cells and Cells Expressing Mutant p53

Bruce C. McKay, Christopher Winrow, Andrew J. Rainbow

Journal:

Photochemistry and Photobiology

Année:

1997

Langue:

english

Fichier:

PDF, 677 KB

english, 1997

9

Reply to “Association between organophosphate exposure and hyperactivity?”

Winrow, Christopher J, Casida, John E, Barlow, Carrolee

Journal:

Nature Genetics

Année:

2003

Langue:

english

Fichier:

PDF, 60 KB

english, 2003

10

Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity

Winrow, Christopher J., Hemming, Matthew L., Allen, Duane M., Quistad, Gary B., Casida, John E., Barlow, Carrolee

Journal:

Nature Genetics

Année:

2003

Langue:

english

Fichier:

PDF, 2.61 MB

english, 2003

11

Refined anatomical isolation of functional sleep circuits exhibits distinctive regional and circadian gene transcriptional profiles

Christopher J. Winrow, Keith Q. Tanis, Alison M. Rigby, Rhonda R. Taylor, Kyle Serikawa, Mollie McWhorter, George Y. Tokiwa, Matthew J. Marton, David J. Stone, Kenneth S. Koblan, John J. Renger

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 3.41 MB

english, 2009

12

Calreticulin modulates the in vitro DNA binding but not the in vivo transcriptional activation by peroxisome proliferator-activated receptor/retinoid X receptor heterodimers

Christopher J. Winrow, Kenji S. Miyata, Sandra L. Marcus, Kimberly Burns, Marek Michalak, John P. Capone, Richard A. Rachubinski

Journal:

Molecular and Cellular Endocrinology

Année:

1995

Langue:

english

Fichier:

PDF, 623 KB

english, 1995

13

Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes

John Hunter, Altaf Kassam, Christopher J. Winrow, Richard A. Rachubinski, John P. Capone

Journal:

Molecular and Cellular Endocrinology

Année:

1996

Langue:

english

Fichier:

PDF, 1.19 MB

english, 1996

14

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

Christopher J. Winrow, Keith Q. Tanis, Duane R. Reiss, Alison M. Rigby, Jason M. Uslaner, Victor N. Uebele, Scott M. Doran, Steven V. Fox, Susan L. Garson, Anthony L. Gotter, David M. Levine, Anthony

Journal:

Neuropharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2010

15

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox, Pamela L. Tannenbaum, Susan L. Garson, Scott M. Doran, Michael J. Breslin, John D. Schreier, Steven V. Fox, Charles M. Harrell, Joanne Ste

Journal:

Neuropharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 982 KB

english, 2012

16

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, T

Journal:

BMC Neuroscience

Année:

2013

Langue:

english

Fichier:

PDF, 790 KB

english, 2013

17

Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement

Uslaner, Jason M., Winrow, Christopher J., Gotter, Anthony L., Roecker, Anthony J., Coleman, Paul J., Hutson, Pete H., Le, Anh D., Renger, John J.

Journal:

Behavioural Brain Research

Année:

2014

Langue:

english

Fichier:

PDF, 560 KB

english, 2014

18

Evidence for orexinergic mechanisms in migraine

Hoffmann, Jan, Supronsinchai, Weera, Akerman, Simon, Andreou, Anna P., Winrow, Christopher J., Renger, John, Hargreaves, Richard, Goadsby, Peter J.

Journal:

Neurobiology of Disease

Année:

2015

Langue:

english

Fichier:

PDF, 682 KB

english, 2015

19

Quantitative Proteomics in Laser Capture Microdissected Sleep Nuclei From Rat Brain

Miller, Ronald A., Winrow, Christopher J., Spellman, Daniel S., Song, Qinghua, Reiss, Duane R., Conway, James P., Taylor, Rhonda R., Coleman, Paul J., Hendrickson, Ronald C., Renger, John J.

Journal:

Journal of Neurogenetics

Année:

2014

Langue:

english

Fichier:

PDF, 612 KB

english, 2014

20

Abeta oligomers as a pharmacodynamic biomarker of secretase therapy in Alzheimer's disease?

Kalinina, Juliya, Michener, Maria S., Smith, Brad E., Parker, Eric, Stone, Julie A., Kennedy, Matthew, Winrow, Christopher J., Savage, Mary J.

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 47 KB

english, 2015

21

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Co

Journal:

Nature Structural and Molecular Biology

Année:

2016

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2016

22

New approach for analyzing self-reporting of insomnia symptoms reveals a high rate of comorbid insomnia across a wide spectrum of chronic diseases

Katic, Bozena, Heywood, James, Turek, Fred, Chiauzzi, Emil, Vaughan, Timothy E., Simacek, Kristina, Wicks, Paul, Jain, Sachin, Winrow, Christopher, Renger, John J.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 589 KB

english, 2015

23

Genome-wide transcriptional profiles of Alzheimer’s disease mouse models and comparison to human gene expression

Marcus, Jacob N., Tanis, Keith, Pearson, Michelle, Wang, Xiaohai, Smith, Sean, Howell, Bonnie, Gustafson, Eric, Winrow, Christopher J.

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 199 KB

english, 2015

24

Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain

McDonald, Terrence, Liang, Hongyu A., Sanoja, Raul, Gotter, Anthony L., Kuduk, Scott D., Coleman, Paul J., Smith, Karen M., Winrow, Christopher J., Renger, John J.

Journal:

Journal of Neurogenetics

Année:

2016

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2016

25

OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO 2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES

Johnson, Philip L., Federici, Lauren M., Fitz, Stephanie D., Renger, John J., Shireman, Brock, Winrow, Christopher J., Bonaventure, Pascal, Shekhar, Anantha

Journal:

Depression and Anxiety

Année:

2015

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2015

26

A CELLULAR EXPRESSION MODEL OF TAU HYPERPHOSPHORYLATION AND AGGREGATION THAT DOES NOT UTILIZE FRONTOTEMPORAL DEMENTIA MUTATIONS

Schachter, Joel B., Cosden, Mali, Meteer, Jeffrey, Majercak, John, Hess, Fred, Niroomand, Shahriar, Renger, John J., Winrow, Christopher J.

Journal:

Alzheimer's & Dementia

Année:

2016

Langue:

english

Fichier:

PDF, 323 KB

english, 2016

27

Preclinical and clinical results of dual orexin receptor antagonist, suvorexant (BELSOMRA®), a novel therapeutic agent for insomnia

Tanaka, Yoshitaka, Aoki, Ikuo, Ishine, Takaaki, Renger, John J., Winrow, Christopher J., Hisada, Satoru

Journal:

Folia Pharmacologica Japonica

Année:

2016

Fichier:

PDF, 1.09 MB

2016

28

The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine

Yao, Lihang Leon, Ramirez, Andres, Roecker, Anthony J., Fox, Steven, Uslaner, Jason, Smith, Sean M., Hodgson, Robert, Coleman, Paul J., Renger, John J., Winrow, Christopher J., Gotter, Anthony L.

Journal:

Journal of Neurochemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2017

29

Blood-Gene Expression Reveals Reduced Circadian Rhythmicity in Individuals Resistant to Sleep Deprivation

Arnardottir, Erna S., Nikonova, Elena V., Shockley, Keith R., Podtelezhnikov, Alexei A., Anafi, Ron C., Tanis, Keith Q., Maislin, Greg, Stone, David J., Renger, John J., Winrow, Christopher J., Pack,

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2014

30

ACUTE ADMINISTRATION OF A BACE INHIBITOR IN HEALTHY HUMANS RESULTS IN A SIGNIFICANT REDUCTION OF Aβ OLIGOMERS IN CEREBROSPINAL FLUID

Kalinina, Juliya, Cheon, Kyeongmi, Stone, Julie, Kennedy, Matthew, Forman, Mark, Egan, Michael F., Tanen, Michael R., Winrow, Christopher J., Savage, Mary J.

Journal:

Alzheimer's & Dementia

Année:

2017

Langue:

english

Fichier:

PDF, 220 KB

english, 2017

31

Altered Sleep and Affect in the Neurotensin Receptor 1 Knockout Mouse

Fitzpatrick, Karrie, Winrow, Christopher J., Gotter, Anthony L., Millstein, Joshua, Arbuzova, Janna, Brunner, Joseph, Kasarskis, Andrew, Vitaterna, Martha H., Renger, John J., Turek, Fred W.

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 893 KB

english, 2012

32

Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory

Eacret, Darrell, Grafe, Laura A., Dobkin, Jane, Gotter, Anthony L., Rengerb, John J., Winrow, Christopher J., Bhatnagar, Seema

Journal:

Behavioural Brain Research

Année:

2018

Langue:

english

Fichier:

PDF, 715 KB

english, 2018

33

Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits

Winrow, Christopher J., Williams, Deanna L., Kasarskis, Andrew, Millstein, Joshua, Laposky, Aaron D., Yang, He S., Mrazek, Karrie, Zhou, Lili, Owens, Joseph R., Radzicki, Daniel, Preuss, Fabian, Schad

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 315 KB

english, 2009

34

Opportunities and perspectives for developing orexin receptor antagonists

Steiner, Michel A., Winrow, Christopher J.

Journal:

Frontiers in Neuroscience

Année:

2014

Langue:

english

Fichier:

PDF, 352 KB

english, 2014

35

Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression

Scarpa, Joseph R., Jiang, Peng, Gao, Vance D., Fitzpatrick, Karrie, Millstein, Joshua, Olker, Christopher, Gotter, Anthony, Winrow, Christopher J., Renger, John J., Kasarskis, Andrew, Turek, Fred W.,

Journal:

Science Advances

Année:

2018

Langue:

english

Fichier:

PDF, 2.77 MB

english, 2018

36

Identification of Causal Genes, Networks, and Transcriptional Regulators of REM Sleep and Wake

Millstein, Joshua, Winrow, Christopher J., Kasarskis, Andrew, Owens, Joseph R., Zhou, Lili, Summa, Keith C., Fitzpatrick, Karrie, Zhang, Bin, Vitaterna, Martha H., Schadt, Eric E., Renger, John J., Tu

Journal:

Année:

2011

Fichier:

PDF, 2.42 MB

2011

37

Identification of Causal Genes, Networks, and Transcriptional Regulators of REM Sleep and Wake

Millstein, Joshua, Winrow, Christopher J., Kasarskis, Andrew, Owens, Joseph R., Zhou, Lili, Summa, Keith C., Fitzpatrick, Karrie, Zhang, Bin, Vitaterna, Martha H., Schadt, Eric E., Renger, John J., Tu

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 2.42 MB

english, 2011